I know Paypal is the world most loved way - payment in the world. But in early when I use Skrill, it doesn't charge me too much fee, higher exchange rate than Paypal and super fast pace withdrawal time (only 12-24 hours). That's reason I loved Skrill so much. But right now, Skrill applied scared fees on my account, and it doesn't send money directly to my local bank account, instead of, they use an intermediary bank for processing transfering, that's reason exchange rate is worse and also the withdrawal time also increase to = Paypal. So current, I prefer Paypal than Skrill a little bit. But no one is best for me.
I am using both of them, Skrill for payment with my broker hotforex and Paypal for my online business.